Bibliografia

1 - Bilia et al.; "St. John’s wort and depression Efficacy, safety and tolerability-an update"; Life Sciences, 2002, 70: 3077–3096

2 - Hamerly et al.; "St. john's wort - overview"

3 - Meinke et al.; "In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo"; European Journal of Pharmaceutics and Biopharmaceutics, 2012, 81: 346–350

4 - Saddiqe et al.; "A review of the antibacterial activity of Hypericum perforatum L."; Journal of Ethnopharmacology, 2010, 131: 511–521

5 - http://toxnet.nlm.nih.gov/cgi-bin/sis/search (acedido em 2013/05/02 )

6 - Belmarker et al.; "Major depressive disorder"; The New England Journal of Medicine, 2008, 358:55-68

7- Butterweek el al.; "St. john's wort role of active compounds for its mechanism of action and efficacy"; Wien med Wochenschr, 2007, 157; 356-361

8 - Henderson et al.; "St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes"; Br J Clin Pharmacol, 2002, 54: 349–356

9 - Mennini et al.; "The antidepressant mechanism of Hypericum perforatum"; Life Sciences, 2004, 75: 1021–1027

10 - Leuner et al.; "Hyperforin—a key constituent of St. John’s wort specifically activates TRPC6 channels"; The FASEB Journal, 2007, 21: 4101-4111

11 - Cabrelle et al.; "Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease"; Journal of Leukocyte Biology, 2008, 83: 212-219

12 - Menichini et al.; "Hypericum perforatum L. subsp. perforatum induces inhibition of free radicals and enhanced phototoxicity in human melanoma cells under ultraviolet light"; Cell Proliferation, 2013, 46: 193–202

13 - Mannel, M.; "Drug Interactions with St John’s Wort Mechanisms and Clinical Implications"; Drug Safety 2004; 27: 773-797

14 - Zhou et al.; "Pharmacokinetic interactions of drugs with St John’s wort"; Journal of Psychopharmacology, 2004, 18: 262–276

15 - Hennessy et al.; " St Johns wort increases expression of P-glycoprotein: implications for drug interactions"; Br J Clin Pharmacol, 2002, 53: 75-82

16 - Cui et al.; "In vitro metabolism of hyperforin in rat liver microsomal systems"; Drug metabolism and disposition, 2004, 32: 32:28

17 - Barnes et al.; "St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties". J Pharm Pharmacol, 2001, 53: 583-600

18 - Roby et al.;"St John's Wort: effect on CYP3A4 activity"; Clin Pharmacol Ther, 2000, 67: 451-7

19 - Kliewer et al.; " An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway"; Cell, 1998, 92: 73-82

20 - Istikoglou et al.; "History and therapeutic properties of Hypericum perforatum from antiquity until today"; Pstchiatrike, 2010, 21: 332-338

21 - Izzo et al.; "Interactions between herbal medicines and prescribed drugs"; Drugs, 2009, 69: 1777-1798

22 - Boyer et al.; "The serotonin syndrome"; N Engl J Med, 2005, 352: 1112-20

23 - http://www.infarmed.pt/infomed/download_ficheiro.php?med_id=31101&tipo_doc=rcm (acedido a 2013/05/05)

24 - Ulbricht et al.; "A ¨Trorough Analysis of the Safety Profile of St. John's wort by the Natural Research Collaboration"; Natural Medicine Journal, 2010, 2 (2): 1-10

25 - http://webmd.com/vitamins-supplements/ingredientmono-329-ST.%20JOHN'S%20WORT.aspx?activeIngredientld=329&activeIngredientName=ST.%JOHN'S%20WORT (acedido a 2013/05/05)

26 - http://www.nature.com/nrd/journal/v1/n4/fig_tab/nrd753_F1 (acedido a 2013/05/05)

27 - https://en.wikipedia.org/wiki/Melanoma (acedido a 2013/05/23)

28 - http://giovannacarvalho.wordpress.com/2013/01/page/2/ (acedido a 2013/05/23)

29 - http://pt.wikipedia.org/wiki/Depress%C3%A3o_nervosa (acedido a 2013/05/05)

30 - http://farmaciavitoria.pt/pt/17-afeccoes-bucais (acedido a 2013/05/05)

31 - http://farmaceutico.planetaclix.pt/dermatite.HTML (acedido a 2013/05/05)

32 -http://www.calesita.com.br/site/blog/?p=1510 (acedido a 2013/05/05)

33 - http://www.draanabelle.com/2012/03/as-gravidas-e-os-anestesicos-locais.HTML (acedido a 2013/05/05)

34 - http://www.fortefarma.com.br/noticias/noticia/3573 (acedido a 2013/05/05)

35 - http://www.geracaobiz.org.mz/?p=804 (acedido a 2013/05/05)

36 - http://www.adrnp-sede.org.pt/insuficienciarenal.HTML (acedido a 2013/05/05)

37 - http://eb1-jdeanha.blogspot.pt/2012/11/o-relogio-misterioso.HTML (acedido a 2013/05/05)

38 - http://vomite.blogspot.pt/2011/04/da-pra-pagar.html (acedido a 2013/05/05)